Aberrant activation of Notch signaling inhibits PROX1 activity to enhance the malignant behavior of thyroid cancer cells
Identifieur interne : 002191 ( Main/Exploration ); précédent : 002190; suivant : 002192Aberrant activation of Notch signaling inhibits PROX1 activity to enhance the malignant behavior of thyroid cancer cells
Auteurs : Dongwon Choi [États-Unis] ; Swapnika Ramu [États-Unis] ; Eunkyung Park [États-Unis] ; Eunson Jung [États-Unis] ; Sara Yang [États-Unis] ; Wonhyeuk Jung [États-Unis] ; Inho Choi [États-Unis, Corée du Sud] ; Sunju Lee [États-Unis] ; Kyu Eui Kim [États-Unis] ; Young Jin Seong [États-Unis] ; Mingu Hong [États-Unis] ; George H. Daghlian [États-Unis] ; Daniel Kim [États-Unis] ; Eugene Shin [États-Unis] ; Jung In Seo [États-Unis] ; Vicken Khatchadourian [États-Unis] ; Mengchen Zou [États-Unis] ; Wei Li [États-Unis] ; Roger E. De Filippo ; Paul J. Kokorowski ; Andy Y. Chang ; Steve S. Kim ; Ana Santin [Brésil] ; Tania Furlanetto [Brésil] ; Sung S. Shin [États-Unis] ; Meng Li [États-Unis] ; Yibu Chen [États-Unis] ; Alex K. Wong [États-Unis] ; Chester J. Koh [États-Unis] ; Jan Geliebter [États-Unis] ; Young-Kwon Hong [États-Unis]Source :
- Cancer research [ 0008-5472 ] ; 2015.
Abstract
Papillary thyroid cancer (PTC) is one of the most common endocrine malignancies associated with significant morbidity and mortality. Although multiple studies have contributed to a better understanding of the genetic alterations underlying this frequently arising disease, the downstream molecular effectors that impact PTC pathogenesis remain to be further defined. Here, we report that the regulator of cell fate specification, PROX1, becomes inactivated in PTC through mRNA downregulation and cytoplasmic mislocalization. Expression studies in clinical specimens revealed that aberrantly activated NOTCH signaling promoted PROX1 downregulation and that cytoplasmic mislocalization significantly altered PROX1 protein stability. Importantly, restoration of PROX1 activity in thyroid carcinoma cells revealed that PROX1 not only enhanced Wnt/β-catenin signaling, but also regulated several genes known to be associated with PTC, including thyroid cancer protein (TC)-1, SERPINA1, and FABP4. Furthermore, PROX1 re-expression suppressed the malignant phenotypes of thyroid carcinoma cells, such as proliferation, motility, adhesion, invasion, anchorage-independent growth, and polyploidy. Moreover, animal xenograft studies demonstrated that restoration of PROX1 severely impeded tumor formation and suppressed the invasiveness and the nuclear/cytoplasmic ratio of PTC cells. Taken together, our findings demonstrate that NOTCH-induced PROX1 inactivation significantly promotes the malignant behavior of thyroid carcinoma, and suggest that PROX1 reactivation may represent a potential therapeutic strategy to attenuate disease progression
Url:
DOI: 10.1158/0008-5472.CAN-15-1199
PubMed: 26609053
PubMed Central: 4738160
Affiliations:
- Brésil, Corée du Sud, États-Unis
- Californie, Rio Grande do Sul, Texas, État de New York
- Los Angeles, Porto Alegre
- Université de Californie du Sud, Université fédérale du Rio Grande do Sul
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 003654
- to stream Pmc, to step Curation: 003653
- to stream Pmc, to step Checkpoint: 001542
- to stream Ncbi, to step Merge: 007B67
- to stream Ncbi, to step Curation: 007B67
- to stream Ncbi, to step Checkpoint: 007B67
- to stream Main, to step Merge: 002194
- to stream Main, to step Curation: 002191
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Aberrant activation of Notch signaling inhibits PROX1 activity to
enhance the malignant behavior of thyroid cancer cells</title>
<author><name sortKey="Choi, Dongwon" sort="Choi, Dongwon" uniqKey="Choi D" first="Dongwon" last="Choi">Dongwon Choi</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ramu, Swapnika" sort="Ramu, Swapnika" uniqKey="Ramu S" first="Swapnika" last="Ramu">Swapnika Ramu</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Park, Eunkyung" sort="Park, Eunkyung" uniqKey="Park E" first="Eunkyung" last="Park">Eunkyung Park</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jung, Eunson" sort="Jung, Eunson" uniqKey="Jung E" first="Eunson" last="Jung">Eunson Jung</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Yang, Sara" sort="Yang, Sara" uniqKey="Yang S" first="Sara" last="Yang">Sara Yang</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jung, Wonhyeuk" sort="Jung, Wonhyeuk" uniqKey="Jung W" first="Wonhyeuk" last="Jung">Wonhyeuk Jung</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Choi, Inho" sort="Choi, Inho" uniqKey="Choi I" first="Inho" last="Choi">Inho Choi</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Pharmaceutical Engineering, College of Life and Health Sciences, Hoseo University, Asan, Chungnam, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Pharmaceutical Engineering, College of Life and Health Sciences, Hoseo University, Asan, Chungnam</wicri:regionArea>
<wicri:noRegion>Chungnam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Sunju" sort="Lee, Sunju" uniqKey="Lee S" first="Sunju" last="Lee">Sunju Lee</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kim, Kyu Eui" sort="Kim, Kyu Eui" uniqKey="Kim K" first="Kyu Eui" last="Kim">Kyu Eui Kim</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Seong, Young Jin" sort="Seong, Young Jin" uniqKey="Seong Y" first="Young Jin" last="Seong">Young Jin Seong</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hong, Mingu" sort="Hong, Mingu" uniqKey="Hong M" first="Mingu" last="Hong">Mingu Hong</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Daghlian, George H" sort="Daghlian, George H" uniqKey="Daghlian G" first="George H." last="Daghlian">George H. Daghlian</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kim, Daniel" sort="Kim, Daniel" uniqKey="Kim D" first="Daniel" last="Kim">Daniel Kim</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Shin, Eugene" sort="Shin, Eugene" uniqKey="Shin E" first="Eugene" last="Shin">Eugene Shin</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Seo, Jung In" sort="Seo, Jung In" uniqKey="Seo J" first="Jung In" last="Seo">Jung In Seo</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Khatchadourian, Vicken" sort="Khatchadourian, Vicken" uniqKey="Khatchadourian V" first="Vicken" last="Khatchadourian">Vicken Khatchadourian</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zou, Mengchen" sort="Zou, Mengchen" uniqKey="Zou M" first="Mengchen" last="Zou">Mengchen Zou</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Dermatology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Dermatology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Li, Wei" sort="Li, Wei" uniqKey="Li W" first="Wei" last="Li">Wei Li</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Dermatology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Dermatology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="De Filippo, Roger E" sort="De Filippo, Roger E" uniqKey="De Filippo R" first="Roger E." last="De Filippo">Roger E. De Filippo</name>
<affiliation><nlm:aff id="A4">Division of Urology Children’s Hospital Los Angeles and Department of Urology Keck School of Medicine University of Southern California</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kokorowski, Paul J" sort="Kokorowski, Paul J" uniqKey="Kokorowski P" first="Paul J." last="Kokorowski">Paul J. Kokorowski</name>
<affiliation><nlm:aff id="A4">Division of Urology Children’s Hospital Los Angeles and Department of Urology Keck School of Medicine University of Southern California</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chang, Andy Y" sort="Chang, Andy Y" uniqKey="Chang A" first="Andy Y." last="Chang">Andy Y. Chang</name>
<affiliation><nlm:aff id="A4">Division of Urology Children’s Hospital Los Angeles and Department of Urology Keck School of Medicine University of Southern California</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kim, Steve S" sort="Kim, Steve S" uniqKey="Kim S" first="Steve S." last="Kim">Steve S. Kim</name>
<affiliation><nlm:aff id="A4">Division of Urology Children’s Hospital Los Angeles and Department of Urology Keck School of Medicine University of Southern California</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Santin, Ana" sort="Santin, Ana" uniqKey="Santin A" first="Ana" last="Santin">Ana Santin</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Basic Health Sciences, Federal University of Health Sciences of Porto Alegre, RS, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Basic Health Sciences, Federal University of Health Sciences of Porto Alegre, RS</wicri:regionArea>
<placeName><region type="state">Rio Grande do Sul</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Furlanetto, Tania" sort="Furlanetto, Tania" uniqKey="Furlanetto T" first="Tania" last="Furlanetto">Tania Furlanetto</name>
<affiliation wicri:level="4"><nlm:aff id="A6">PostGraduation Program in Medicine: Medical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>PostGraduation Program in Medicine: Medical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS</wicri:regionArea>
<placeName><region type="state">Rio Grande do Sul</region>
<settlement type="city">Porto Alegre</settlement>
</placeName>
<orgName type="university">Université fédérale du Rio Grande do Sul</orgName>
</affiliation>
</author>
<author><name sortKey="Shin, Sung S" sort="Shin, Sung S" uniqKey="Shin S" first="Sung S." last="Shin">Sung S. Shin</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Pathology, Kaiser Permanente Medical Center, Fontana, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Pathology, Kaiser Permanente Medical Center, Fontana</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Li, Meng" sort="Li, Meng" uniqKey="Li M" first="Meng" last="Li">Meng Li</name>
<affiliation wicri:level="4"><nlm:aff id="A8">Bioinformatics Service Program, Norris Medical Library, University of Southern California</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Chen, Yibu" sort="Chen, Yibu" uniqKey="Chen Y" first="Yibu" last="Chen">Yibu Chen</name>
<affiliation wicri:level="4"><nlm:aff id="A8">Bioinformatics Service Program, Norris Medical Library, University of Southern California</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Wong, Alex K" sort="Wong, Alex K" uniqKey="Wong A" first="Alex K." last="Wong">Alex K. Wong</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Koh, Chester J" sort="Koh, Chester J" uniqKey="Koh C" first="Chester J." last="Koh">Chester J. Koh</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Division of Pediatric Urology, Texas Children’s Hospital, Baylor College of Medicine, Houston, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Division of Pediatric Urology, Texas Children’s Hospital, Baylor College of Medicine, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Geliebter, Jan" sort="Geliebter, Jan" uniqKey="Geliebter J" first="Jan" last="Geliebter">Jan Geliebter</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Department of Microbiology & Immunology, Department of Otolaryngology, New York Medical College, Valhalla, New York</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Microbiology & Immunology, Department of Otolaryngology, New York Medical College, Valhalla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26609053</idno>
<idno type="pmc">4738160</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738160</idno>
<idno type="RBID">PMC:4738160</idno>
<idno type="doi">10.1158/0008-5472.CAN-15-1199</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">003654</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003654</idno>
<idno type="wicri:Area/Pmc/Curation">003653</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003653</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001542</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001542</idno>
<idno type="wicri:Area/Ncbi/Merge">007B67</idno>
<idno type="wicri:Area/Ncbi/Curation">007B67</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">007B67</idno>
<idno type="wicri:doubleKey">0008-5472:2015:Choi D:aberrant:activation:of</idno>
<idno type="wicri:Area/Main/Merge">002194</idno>
<idno type="wicri:Area/Main/Curation">002191</idno>
<idno type="wicri:Area/Main/Exploration">002191</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Aberrant activation of Notch signaling inhibits PROX1 activity to
enhance the malignant behavior of thyroid cancer cells</title>
<author><name sortKey="Choi, Dongwon" sort="Choi, Dongwon" uniqKey="Choi D" first="Dongwon" last="Choi">Dongwon Choi</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ramu, Swapnika" sort="Ramu, Swapnika" uniqKey="Ramu S" first="Swapnika" last="Ramu">Swapnika Ramu</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Park, Eunkyung" sort="Park, Eunkyung" uniqKey="Park E" first="Eunkyung" last="Park">Eunkyung Park</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jung, Eunson" sort="Jung, Eunson" uniqKey="Jung E" first="Eunson" last="Jung">Eunson Jung</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Yang, Sara" sort="Yang, Sara" uniqKey="Yang S" first="Sara" last="Yang">Sara Yang</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Jung, Wonhyeuk" sort="Jung, Wonhyeuk" uniqKey="Jung W" first="Wonhyeuk" last="Jung">Wonhyeuk Jung</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Choi, Inho" sort="Choi, Inho" uniqKey="Choi I" first="Inho" last="Choi">Inho Choi</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Pharmaceutical Engineering, College of Life and Health Sciences, Hoseo University, Asan, Chungnam, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Pharmaceutical Engineering, College of Life and Health Sciences, Hoseo University, Asan, Chungnam</wicri:regionArea>
<wicri:noRegion>Chungnam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Sunju" sort="Lee, Sunju" uniqKey="Lee S" first="Sunju" last="Lee">Sunju Lee</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kim, Kyu Eui" sort="Kim, Kyu Eui" uniqKey="Kim K" first="Kyu Eui" last="Kim">Kyu Eui Kim</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Seong, Young Jin" sort="Seong, Young Jin" uniqKey="Seong Y" first="Young Jin" last="Seong">Young Jin Seong</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hong, Mingu" sort="Hong, Mingu" uniqKey="Hong M" first="Mingu" last="Hong">Mingu Hong</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Daghlian, George H" sort="Daghlian, George H" uniqKey="Daghlian G" first="George H." last="Daghlian">George H. Daghlian</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kim, Daniel" sort="Kim, Daniel" uniqKey="Kim D" first="Daniel" last="Kim">Daniel Kim</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Shin, Eugene" sort="Shin, Eugene" uniqKey="Shin E" first="Eugene" last="Shin">Eugene Shin</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Seo, Jung In" sort="Seo, Jung In" uniqKey="Seo J" first="Jung In" last="Seo">Jung In Seo</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Khatchadourian, Vicken" sort="Khatchadourian, Vicken" uniqKey="Khatchadourian V" first="Vicken" last="Khatchadourian">Vicken Khatchadourian</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Zou, Mengchen" sort="Zou, Mengchen" uniqKey="Zou M" first="Mengchen" last="Zou">Mengchen Zou</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Dermatology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Dermatology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Li, Wei" sort="Li, Wei" uniqKey="Li W" first="Wei" last="Li">Wei Li</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Dermatology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Dermatology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="De Filippo, Roger E" sort="De Filippo, Roger E" uniqKey="De Filippo R" first="Roger E." last="De Filippo">Roger E. De Filippo</name>
<affiliation><nlm:aff id="A4">Division of Urology Children’s Hospital Los Angeles and Department of Urology Keck School of Medicine University of Southern California</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kokorowski, Paul J" sort="Kokorowski, Paul J" uniqKey="Kokorowski P" first="Paul J." last="Kokorowski">Paul J. Kokorowski</name>
<affiliation><nlm:aff id="A4">Division of Urology Children’s Hospital Los Angeles and Department of Urology Keck School of Medicine University of Southern California</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chang, Andy Y" sort="Chang, Andy Y" uniqKey="Chang A" first="Andy Y." last="Chang">Andy Y. Chang</name>
<affiliation><nlm:aff id="A4">Division of Urology Children’s Hospital Los Angeles and Department of Urology Keck School of Medicine University of Southern California</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kim, Steve S" sort="Kim, Steve S" uniqKey="Kim S" first="Steve S." last="Kim">Steve S. Kim</name>
<affiliation><nlm:aff id="A4">Division of Urology Children’s Hospital Los Angeles and Department of Urology Keck School of Medicine University of Southern California</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Santin, Ana" sort="Santin, Ana" uniqKey="Santin A" first="Ana" last="Santin">Ana Santin</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Basic Health Sciences, Federal University of Health Sciences of Porto Alegre, RS, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Department of Basic Health Sciences, Federal University of Health Sciences of Porto Alegre, RS</wicri:regionArea>
<placeName><region type="state">Rio Grande do Sul</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Furlanetto, Tania" sort="Furlanetto, Tania" uniqKey="Furlanetto T" first="Tania" last="Furlanetto">Tania Furlanetto</name>
<affiliation wicri:level="4"><nlm:aff id="A6">PostGraduation Program in Medicine: Medical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>PostGraduation Program in Medicine: Medical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS</wicri:regionArea>
<placeName><region type="state">Rio Grande do Sul</region>
<settlement type="city">Porto Alegre</settlement>
</placeName>
<orgName type="university">Université fédérale du Rio Grande do Sul</orgName>
</affiliation>
</author>
<author><name sortKey="Shin, Sung S" sort="Shin, Sung S" uniqKey="Shin S" first="Sung S." last="Shin">Sung S. Shin</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Department of Pathology, Kaiser Permanente Medical Center, Fontana, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Pathology, Kaiser Permanente Medical Center, Fontana</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Li, Meng" sort="Li, Meng" uniqKey="Li M" first="Meng" last="Li">Meng Li</name>
<affiliation wicri:level="4"><nlm:aff id="A8">Bioinformatics Service Program, Norris Medical Library, University of Southern California</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Chen, Yibu" sort="Chen, Yibu" uniqKey="Chen Y" first="Yibu" last="Chen">Yibu Chen</name>
<affiliation wicri:level="4"><nlm:aff id="A8">Bioinformatics Service Program, Norris Medical Library, University of Southern California</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Wong, Alex K" sort="Wong, Alex K" uniqKey="Wong A" first="Alex K." last="Wong">Alex K. Wong</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Koh, Chester J" sort="Koh, Chester J" uniqKey="Koh C" first="Chester J." last="Koh">Chester J. Koh</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Division of Pediatric Urology, Texas Children’s Hospital, Baylor College of Medicine, Houston, Texas</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Division of Pediatric Urology, Texas Children’s Hospital, Baylor College of Medicine, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Geliebter, Jan" sort="Geliebter, Jan" uniqKey="Geliebter J" first="Jan" last="Geliebter">Jan Geliebter</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Department of Microbiology & Immunology, Department of Otolaryngology, New York Medical College, Valhalla, New York</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Microbiology & Immunology, Department of Otolaryngology, New York Medical College, Valhalla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Division of Plastic and Reconstructive Surgery, Department of Surgery, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Cancer research</title>
<idno type="ISSN">0008-5472</idno>
<idno type="eISSN">1538-7445</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P2">Papillary thyroid cancer (PTC) is one of the most common endocrine
malignancies associated with significant morbidity and mortality. Although
multiple studies have contributed to a better understanding of the genetic
alterations underlying this frequently arising disease, the downstream molecular
effectors that impact PTC pathogenesis remain to be further defined. Here, we
report that the regulator of cell fate specification, PROX1, becomes inactivated
in PTC through mRNA downregulation and cytoplasmic mislocalization. Expression
studies in clinical specimens revealed that aberrantly activated NOTCH signaling
promoted PROX1 downregulation and that cytoplasmic mislocalization significantly
altered PROX1 protein stability. Importantly, restoration of PROX1 activity in
thyroid carcinoma cells revealed that PROX1 not only enhanced
Wnt/β-catenin signaling, but also regulated several genes known to be
associated with PTC, including thyroid cancer protein (TC)-1, SERPINA1, and
FABP4. Furthermore, PROX1 re-expression suppressed the malignant phenotypes of
thyroid carcinoma cells, such as proliferation, motility, adhesion, invasion,
anchorage-independent growth, and polyploidy. Moreover, animal xenograft studies
demonstrated that restoration of PROX1 severely impeded tumor formation and
suppressed the invasiveness and the nuclear/cytoplasmic ratio of PTC cells.
Taken together, our findings demonstrate that NOTCH-induced PROX1 inactivation
significantly promotes the malignant behavior of thyroid carcinoma, and suggest
that PROX1 reactivation may represent a potential therapeutic strategy to
attenuate disease progression</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Brésil</li>
<li>Corée du Sud</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Rio Grande do Sul</li>
<li>Texas</li>
<li>État de New York</li>
</region>
<settlement><li>Los Angeles</li>
<li>Porto Alegre</li>
</settlement>
<orgName><li>Université de Californie du Sud</li>
<li>Université fédérale du Rio Grande do Sul</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Chang, Andy Y" sort="Chang, Andy Y" uniqKey="Chang A" first="Andy Y." last="Chang">Andy Y. Chang</name>
<name sortKey="De Filippo, Roger E" sort="De Filippo, Roger E" uniqKey="De Filippo R" first="Roger E." last="De Filippo">Roger E. De Filippo</name>
<name sortKey="Kim, Steve S" sort="Kim, Steve S" uniqKey="Kim S" first="Steve S." last="Kim">Steve S. Kim</name>
<name sortKey="Kokorowski, Paul J" sort="Kokorowski, Paul J" uniqKey="Kokorowski P" first="Paul J." last="Kokorowski">Paul J. Kokorowski</name>
</noCountry>
<country name="États-Unis"><region name="Californie"><name sortKey="Choi, Dongwon" sort="Choi, Dongwon" uniqKey="Choi D" first="Dongwon" last="Choi">Dongwon Choi</name>
</region>
<name sortKey="Chen, Yibu" sort="Chen, Yibu" uniqKey="Chen Y" first="Yibu" last="Chen">Yibu Chen</name>
<name sortKey="Choi, Inho" sort="Choi, Inho" uniqKey="Choi I" first="Inho" last="Choi">Inho Choi</name>
<name sortKey="Daghlian, George H" sort="Daghlian, George H" uniqKey="Daghlian G" first="George H." last="Daghlian">George H. Daghlian</name>
<name sortKey="Geliebter, Jan" sort="Geliebter, Jan" uniqKey="Geliebter J" first="Jan" last="Geliebter">Jan Geliebter</name>
<name sortKey="Hong, Mingu" sort="Hong, Mingu" uniqKey="Hong M" first="Mingu" last="Hong">Mingu Hong</name>
<name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name>
<name sortKey="Jung, Eunson" sort="Jung, Eunson" uniqKey="Jung E" first="Eunson" last="Jung">Eunson Jung</name>
<name sortKey="Jung, Wonhyeuk" sort="Jung, Wonhyeuk" uniqKey="Jung W" first="Wonhyeuk" last="Jung">Wonhyeuk Jung</name>
<name sortKey="Khatchadourian, Vicken" sort="Khatchadourian, Vicken" uniqKey="Khatchadourian V" first="Vicken" last="Khatchadourian">Vicken Khatchadourian</name>
<name sortKey="Kim, Daniel" sort="Kim, Daniel" uniqKey="Kim D" first="Daniel" last="Kim">Daniel Kim</name>
<name sortKey="Kim, Kyu Eui" sort="Kim, Kyu Eui" uniqKey="Kim K" first="Kyu Eui" last="Kim">Kyu Eui Kim</name>
<name sortKey="Koh, Chester J" sort="Koh, Chester J" uniqKey="Koh C" first="Chester J." last="Koh">Chester J. Koh</name>
<name sortKey="Lee, Sunju" sort="Lee, Sunju" uniqKey="Lee S" first="Sunju" last="Lee">Sunju Lee</name>
<name sortKey="Li, Meng" sort="Li, Meng" uniqKey="Li M" first="Meng" last="Li">Meng Li</name>
<name sortKey="Li, Wei" sort="Li, Wei" uniqKey="Li W" first="Wei" last="Li">Wei Li</name>
<name sortKey="Park, Eunkyung" sort="Park, Eunkyung" uniqKey="Park E" first="Eunkyung" last="Park">Eunkyung Park</name>
<name sortKey="Ramu, Swapnika" sort="Ramu, Swapnika" uniqKey="Ramu S" first="Swapnika" last="Ramu">Swapnika Ramu</name>
<name sortKey="Seo, Jung In" sort="Seo, Jung In" uniqKey="Seo J" first="Jung In" last="Seo">Jung In Seo</name>
<name sortKey="Seong, Young Jin" sort="Seong, Young Jin" uniqKey="Seong Y" first="Young Jin" last="Seong">Young Jin Seong</name>
<name sortKey="Shin, Eugene" sort="Shin, Eugene" uniqKey="Shin E" first="Eugene" last="Shin">Eugene Shin</name>
<name sortKey="Shin, Sung S" sort="Shin, Sung S" uniqKey="Shin S" first="Sung S." last="Shin">Sung S. Shin</name>
<name sortKey="Wong, Alex K" sort="Wong, Alex K" uniqKey="Wong A" first="Alex K." last="Wong">Alex K. Wong</name>
<name sortKey="Yang, Sara" sort="Yang, Sara" uniqKey="Yang S" first="Sara" last="Yang">Sara Yang</name>
<name sortKey="Zou, Mengchen" sort="Zou, Mengchen" uniqKey="Zou M" first="Mengchen" last="Zou">Mengchen Zou</name>
</country>
<country name="Corée du Sud"><noRegion><name sortKey="Choi, Inho" sort="Choi, Inho" uniqKey="Choi I" first="Inho" last="Choi">Inho Choi</name>
</noRegion>
</country>
<country name="Brésil"><region name="Rio Grande do Sul"><name sortKey="Santin, Ana" sort="Santin, Ana" uniqKey="Santin A" first="Ana" last="Santin">Ana Santin</name>
</region>
<name sortKey="Furlanetto, Tania" sort="Furlanetto, Tania" uniqKey="Furlanetto T" first="Tania" last="Furlanetto">Tania Furlanetto</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002191 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002191 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:4738160 |texte= Aberrant activation of Notch signaling inhibits PROX1 activity to enhance the malignant behavior of thyroid cancer cells }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26609053" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |